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1H-NMR Analysis of Metabolic Changes Induced by Snf1/AMP-Activated Protein Kinase During Environmental Stress Responses.
Mycobiology ( IF 1.9 ) Pub Date : 2019-07-01 , DOI: 10.1080/12298093.2019.1625854
Jiyoung Kim 1 , Junsang Oh 2 , Deok-Hyo Yoon 2 , Gi-Ho Sung 2, 3
Affiliation  

AMP-activated protein kinase sucrose non-fermenting 1 (Snf1) is a representative regulator of energy status that maintains cellular energy homeostasis. In addition, Snf1 is involved in the mediation of environmental stress such as salt stress. Snf1 regulates metabolic enzymes such as acetyl-CoA carboxylase, indicating a possible role for Snf1 in metabolic regulation. In this article, we performed nuclear magnetic resonance (NMR) spectroscopy to profile the metabolic changes induced by Snf1 under environmental stress. According to our NMR data, we suggest that Snf1 plays a role in regulating cellular concentrations of a variety of metabolites during environmental stress responses.



中文翻译:

1H-NMR分析在环境应激反应中由Snf1 / AMP激活的蛋白激酶引起的代谢变化。

AMP活化蛋白激酶非发酵蔗糖1(Snf1)是能量状态的代表调节剂,可维持细胞能量稳态。此外,Snf1参与环境胁迫(如盐胁迫)的介导。Snf1调节代谢酶,例如乙酰辅酶A羧化酶,表明Snf1在代谢调节中可能发挥作用。在本文中,我们进行了核磁共振(NMR)光谱分析,以描述在环境压力下Snf1诱导的代谢变化。根据我们的NMR数据,我们建议Snf1在环境应激反应期间在调节各种代谢物的细胞浓度中发挥作用。

更新日期:2019-07-01
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