Soy protein isolate (SPI) protein/polymer composite hydrogels (PPCGs) are fabricated in a urea solution of SPI using acrylic acid as monomer, ammonium persulphate (APS) as initiator, and N,N‐methylenebisacrylamide (BIS) and glutaraldehyde (GA) as cross‐linking agents. The scanning electron microscope (SEM) results show that SPI/polyacrylic (PAA) composite hydrogels formed network structure. In particular, in the absence of cross‐linking agent (GA), the network structure of composite hydrogels is also formed by BIS cross‐linking chains of PAA and the hydrophobic interactions between peptides from SPI and chain of PAA. In addition, composite hydrogels have good water absorption and present excellent pH sensitivity. Composite hydrogels adsorb bovine serum albumin (BSA) with higher adsorption capacity. BSA is the control released in pH 7.4 buffers and the accumulative release ratio achieved is 90%. It will be expected that these protein/polymer composite hydrogels could be applied for drug sustained release materials.

中文翻译：

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基于大豆分离蛋白的复合水凝胶的制备及其受控的球状蛋白递送。

以丙烯酸为单体、过硫酸铵（APS）为引发剂、N,N-亚甲基双丙烯酰胺（BIS）和戊二醛（GA）在SPI的尿素溶液中制备大豆分离蛋白（SPI）蛋白质/聚合物复合水凝胶（PPCG）作为交联剂。扫描电镜(SEM)结果表明SPI/聚丙烯酸(PAA)复合水凝胶形成了网络结构。特别是，在没有交联剂（GA）的情况下，复合水凝胶的网络结构也是由PAA的BIS交联链以及SPI肽和PAA链之间的疏水相互作用形成的。此外，复合水凝胶具有良好的吸水性和优异的pH敏感性。复合水凝胶对牛血清白蛋白（BSA）的吸附具有更高的吸附能力。BSA 是在 pH 7.4 缓冲液中释放的对照，累计释放率为 90%。预计这些蛋白质/聚合物复合水凝胶可应用于药物缓释材料。