Juvenile idiopathic arthritis (JIA) is one of the most common autoimmune diseases in children. Our study aimed to evaluate the peripheral blood B and T lymphocyte subpopulations in children with JIA. This case-control study included 20 children with JIA as well as 20 healthy children with matching age and sex as a control group. All patients included in the study were in activity as determined by visual analog scale. In addition to complete clinical evaluation, basic investigations, peripheral blood B and T lymphocyte subpopulations were done to all participants by flow cytometry. JIA patients displayed a significant decrease in IgM memory B lymphocytes, switched memory B lymphocytes, and total memory B lymphocytes when compared to the healthy controls. The percentages of naïve B lymphocytes were significantly increased in JIA patients than in controls. Total T lymphocytes, CD8+CD28null cells, and CD4+CD28null cells were significantly increased in JIA patients as compared to controls. In conclusion; JIA patients have an alteration in both B and T lymphocytes with the predisposition of memory cells which may have a role in sustaining the JIA disease activity.

中文翻译：

---

活动性幼年特发性关节炎儿童的外周血B和T细胞谱。

青少年特发性关节炎（JIA）是儿童中最常见的自身免疫性疾病之一。我们的研究旨在评估JIA儿童的外周血B和T淋巴细胞亚群。该病例对照研究纳入了20名JIA儿童以及20名年龄和性别相匹配的健康儿童作为对照组。通过视觉模拟量表确定的该研究中包括的所有患者都处于活动状态。除了完整的临床评估外，还通过流式细胞术对所有参与者进行了基础研究，外周血B和T淋巴细胞亚群。与健康对照组相比，JIA患者的IgM记忆B淋巴细胞，转换记忆B淋巴细胞和总记忆B淋巴细胞显着减少。与对照组相比，JIA患者的幼稚B淋巴细胞百分比显着增加。与对照组相比，JIA患者的总T淋巴细胞，CD8 + CD28null细胞和CD4 + CD28null细胞显着增加。结论; JIA患者的B淋巴细胞和T淋巴细胞都有变化，其易感性可能是维持JIA疾病活动的记忆细胞。