Exposure to air pollution is associated with enhanced risk of developing asthma, notably in the presence of genetic risk factors. Interaction analyses have shown that both outdoor and indoor air pollution interact with genetic variability to increase the incidence of asthma. In this review, we summarize recent progress in candidate gene-based studies, as well as genome-wide gene-air pollution interaction studies. Advances in epigenetics have provided evidence for DNA methylation as a mediator in gene-air pollution interactions. Emerging strategies for study design and statistical analyses may improve power in future studies. Improved air pollution exposure assessment methods and asthma endo-typing can also be expected to increase the ability to detect biologically driven gene-air pollution interaction effects.

中文翻译：

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哮喘风险中环境污染物与遗传易感性之间的相互作用。

暴露于空气污染会增加患哮喘的风险，尤其是在有遗传危险因素的情况下。相互作用分析表明，室外和室内空气污染都与遗传变异相互作用，从而增加了哮喘的发病率。在这篇综述中，我们总结了基于候选基因的研究以及全基因组范围的基因-空气污染相互作用研究的最新进展。表观遗传学的进展为DNA甲基化作为基因-空气污染相互作用的媒介提供了证据。研究设计和统计分析的新兴策略可能会提高未来研究的能力。改进的空气污染暴露评估方法和哮喘内在分型也有望提高检测生物驱动基因-空气污染相互作用影响的能力。