The endosomal system plays an essential role in cell homeostasis by controlling cellular signaling, nutrient sensing, cell polarity and cell migration. However, its place in the regulation of tissue, organ and whole body physiology is less well understood. Recent studies have revealed an important role for the endosomal system in regulating glucose and lipid homeostasis, with implications for metabolic disorders such as type 2 diabetes, hypercholesterolemia and non-alcoholic fatty liver disease. By taking insights from in vitro studies of endocytosis and exploring their effects on metabolism, we can begin to connect the fields of endosomal transport and metabolic homeostasis. In this review, we explore current understanding of how the endosomal system influences the systemic regulation of glucose and lipid metabolism in mice and humans. We highlight exciting new insights that help translate findings from single cells to a wider physiological level and open up new directions for endosomal research.

中文翻译：

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通过内体系统进行代谢调节。

内体系统通过控制细胞信号传导、营养感应、细胞极性和细胞迁移在细胞稳态中发挥重要作用。然而，它在组织、器官和全身生理学调节中的地位尚不清楚。最近的研究揭示了内体系统在调节葡萄糖和脂质稳态中的重要作用，对 2 型糖尿病、高胆固醇血症和非酒精性脂肪肝等代谢性疾病具有影响。通过从胞吞作用的体外研究中获取见解并探索它们对代谢的影响，我们可以开始将内体转运和代谢稳态领域联系起来。在这篇综述中，我们探讨了目前对内体系统如何影响小鼠和人类葡萄糖和脂质代谢的系统调节的理解。我们重点介绍令人兴奋的新见解，这些见解有助于将单细胞的发现转化为更广泛的生理水平，并为内体研究开辟新方向。