Skeletal muscles have an immense ability to regenerate from the muscle stem cells called satellite cells. The process of skeletal muscle regeneration is called myogenesis, which starts with activation of quiescent satellite cells immediately after muscle injury followed by proliferation and fusion of myoblasts into myotubes. Myogenesis is orchestrated through the expression of a specific set of genes which, at each step regulated by complex gene regulatory networks. Besides the well-established roles of transcription factors, increasing evidence demonstrated that circular (circ)RNAs modulate gene expression during myogenesis and are involved in muscle-related diseases. Here we review the recent findings of circRNAs involved in myogenesis.

中文翻译：

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环状RNA在肌发生中。

骨骼肌具有从称为卫星细胞的肌肉干细胞再生的巨大能力。骨骼肌再生的过程称为肌发生，该过程始于在肌肉受伤后立即激活静止的卫星细胞，然后是成肌细胞增殖和融合成肌管。通过一组特定基因的表达来协调肌发生，该基因在每一步都由复杂的基因调控网络调控。除了已确立的转录因子的作用外，越来越多的证据表明，环状（circ）RNA在肌发生过程中调节基因表达，并参与肌肉相关疾病。在这里，我们回顾了参与成肌的circRNA的最新发现。