This study examined the relationship between cognitive change and instrumental activities of daily living (IADL) in a large, national, population-based sample. Cognitive change was assessed via verbal fluency, word list learning (WLL), and word list delayed recall (WLD). Incident cognitive impairment was defined by change in Six-Item Screener (SIS) status over a period of 10 years. Impaired IADL was defined as self-reported difficulty or needing assistance performing any IADL at Year 10. A one-word decrease in WLL over a 10-year span increased the odds of impaired IADL by 16% (95% CI 1.08-1.24) and incident cognitive impairment increased the odds of impaired IADL by 59% (95% CI 1.36-1.85) when adjusting for demographic factors, health-related behaviors, vascular risk factors and disease, and depressive symptoms. Cognitive change most strongly predicted impairment in managing finances (OR 2.47, 95% CI 2.04-3.00) and driving (OR 2.06, 95% CI 1.73-2.44).

中文翻译：

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纵向认知变化与一般人群自我报告的IADL的关系。

这项研究在一个大型的，全国性的，以人群为基础的样本中研究了认知变化与日常生活工具活动（IADL）之间的关系。通过口语流利度，单词表学习（WLL）和单词表延迟回忆（WLD）评估认知变化。事件性认知障碍是通过十年内六项筛查（SIS）状态的变化来定义的。IADL受损的定义为在10年级自我报告的困难或需要协助才能完成任何IADL。在10年的时间里，WLL下降了一个字就使IADL受损的几率提高了16％（95％CI 1.08-1.24），进行人口统计学因素，健康相关行为，血管危险因素和疾病以及抑郁症状的调整后，事件性认知障碍使IADL受损的几率增加了59％（95％CI 1.36-1.85）。