Controversy surrounds the role of cytomegalovirus (CMV) in glioblastoma (GBM). However, several studies have shown that CMV nucleic acids and proteins are present within GBM tumor tissue. CMV has been implicated in GBM pathogenesis by affecting tumor stem cell factors, angiogenesis and immune pathways. Anti-viral therapy has not been found to definitively improve outcomes for patients with GBM. Several studies have leveraged CMV by targeting CMV antigens using ex-vivo expanded T cells or dendritic cell vaccines. The initial results from these studies are promising and larger studies are underway.

中文翻译：

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CMV在胶质母细胞瘤中的作用及其对免疫治疗策略的影响。

争议围绕着巨细胞病毒（CMV）在成胶质细胞瘤（GBM）中的作用。但是，一些研究表明，CMV核酸和蛋白质存在于GBM肿瘤组织中。通过影响肿瘤干细胞因子，血管生成和免疫途径，CMV已与GBM发病机制有关。尚未发现抗病毒治疗可以最终改善GBM患者的预后。几项研究利用离体扩增T细胞或树突状细胞疫苗靶向CMV抗原，从而利用了CMV。这些研究的初步结果令人鼓舞，并且正在进行较大的研究。