The recent Research Framework proposed by the US National Institute on Aging and the Alzheimer’s Association (NIA-AA) recommends that Alzheimer’s disease be defined by its specific biology rather than by non-specific neurodegenerative and syndromal features. By affirming markers of abnormal Aβ and tau proteins as the essential pathobiological signature of Alzheimer’s disease, the Framework tacitly reinforces the amyloid (Aβ) cascade as the leading theory of Alzheimer pathogenesis. In light of recent evidence that the cascade is driven by the misfolding and templated aggregation of Aβ and tau, we believe that an empirically grounded Standard Model of Alzheimer’s pathogenesis is within reach. A Standard Model can clarify and consolidate existing information, contextualize risk factors and the complex disease phenotype, identify testable hypotheses for future research, and pave the most direct path to effective prevention and treatment.

美国国家老龄研究所和阿尔茨海默氏症协会（NIA-AA）提出的最新研究框架建议，阿尔茨海默氏病应通过其特定的生物学来定义，而不是通过非特定的神经退行性和综合征特征来定义。通过确认异常Aβ和tau蛋白的标志物是阿尔茨海默氏病的必不可少的病理生物学特征，该框架默认增强了淀粉样蛋白（Aβ）级联反应，这是阿尔茨海默氏病发病机理的主要理论。鉴于最近的证据表明级联反应是由Aβ和tau的错误折叠和模板化聚集驱动的，我们认为以经验为基础的阿尔茨海默氏病发病机理标准模型已经可以实现。标准模型可以阐明和巩固现有信息，根据风险因素和复杂的疾病表型，