The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer-related mortality. Once established, metastasis is devastating, but only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanisms for metastatic colonization. We review the metastatic traits that allow cancer cells to colonize distinct organ sites.

中文翻译：

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远距离生存：特定器官的转移。

重要器官转移的临床表现是癌症进展的最后阶段，也是癌症相关死亡率的主要原因。一旦建立，转移将是​​毁灭性的，但是仅一小部分离开肿瘤的癌细胞成功地浸润，存活并最终超越了远处的器官。在新近入侵的微环境中挑战癌细胞的瓶颈是器官特异性的，因此需要不同的转移定植机制。我们回顾了允许癌细胞在不同器官部位定殖的转移性状。