Deregulation of various components of the immune system has been reported in the inflamed gut of Crohn's disease (CD) patients. Innate lymphoid cells (ILCs) are novel innate effector lymphocytes which can rapidly respond to danger signals, from invading pathogens or tissue damage, to maintain homeostasis, especially along the mucosal surfaces. The purpose of this study is to compare composition of the intestinal ILCs subsets of CD patients with differential inflammatory conditions of the terminal ileum, which are marked by distinct histological appearances and mucosal profiles of cytokines. We observed alterations in the frequency of Lineage(-)CRTH2(-)CD45(+)NKp44(-)CD117(-)CD127(+)ILC subset in the inflamed terminal ileum.

中文翻译：

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克罗恩病患者发炎的末端回肠中沿袭（-）CRTH2（-）CD45（+）NKp44（-）CD117（-）CD127（+）ILC亚群的差异频率。

在克罗恩病（CD）患者的肠道发炎中，免疫系统各种成分的失调已有报道。先天性淋巴细胞（ILC）是新型先天性效应淋巴细胞，可以快速响应来自入侵病原体或组织损伤的危险信号，以维持体内稳态，尤其是沿粘膜表面的动态平衡。这项研究的目的是比较具有回肠末端不同炎症状况的CD患者肠道ILC亚群的组成，其特征在于细胞因子的独特组织学表现和粘膜特征。我们观察到发炎的末端回肠中沿袭（-）CRTH2（-）CD45（+）NKp44（-）CD117（-）CD127（+）ILC子集的频率发生了变化。