Sirtuins (Sirts) compose a family of NAD(+)-dependent deacetylases and/or ADP-ribosyltransferases, which have been implicated in aging, metabolism, and tolerance to oxidative stress. Many of the biological processes regulated by Sirts result from the adaptation of complex gene-expression programs to the energetic state of the cell, sensed through NAD(+) levels. To that respect, Sirts, and particularly the founding member of the family Sirt1, have emerged as important regulators of transcription, which they modulate both positively and negatively by targeting histones and transcriptional complex regulatory proteins. This review will focus on recent advances that have started deciphering how mammalian Sirts regulate transcriptional networks and thereby control physiology.

中文翻译：

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Sirtuins 在哺乳动物生理协调中的转录目标。

Sirtuins (Sirts) 由 NAD(+) 依赖性脱乙酰酶和/或 ADP-核糖基转移酶家族组成，这些酶与衰老、代谢和对氧化应激的耐受性有关。Sirts 调控的许多生物过程是复杂基因表达程序适应细胞能量状态的结果，通过 NAD(+) 水平感知。在这方面，Sirts，尤其是 Sirt1 家族的创始成员，已经成为重要的转录调节因子，它们通过靶向组蛋白和转录复合调节蛋白来正向和负向调节。本综述将重点关注最近已经开始破译哺乳动物 Sirts 如何调节转录网络从而控制生理学的进展。