Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in understanding the migration of the ovarian border cells, embryonic blood cells, primordial germ cells, somatic gonadal precursors, and tracheal cells. Comparison of genes that regulate these processes to those that promote tumorigenesis and metastasis in mammals demonstrates that studies in fruit flies are uncovering new genes highly relevant to cancer biology.

中文翻译：

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驱动果蝇入侵和迁移的基因。

成功的细胞迁移取决于对运动时间的仔细调节、运动细胞的引导以及细胞内的细胞骨架和粘附变化。这篇综述着重于细胞自主作用以促进果蝇细胞迁移的这些方面的基因。我们讨论了了解卵巢边缘细胞、胚胎血细胞、原始生殖细胞、体细胞性腺前体细胞和气管细胞迁移的最新进展。将调节这些过程的基因与促进哺乳动物肿瘤发生和转移的基因进行比较表明，对果蝇的研究正在发现与癌症生物学高度相关的新基因。