Adenosine receptors have been the target of intense research with respect to potential use of selective ligands in a variety of therapeutic areas. Caffeine and theophylline are adenosine receptor antagonists, and over the past three decades a wide range of selective agonists and antagonists for adenosine receptor subtypes have been developed. A complication to the therapeutic use of adenosine receptor ligands is the observation that the effects of acute administration of a particular ligand can be diametrically opposite to the chronic effects of the same ligand. This 'effect inversion' is discussed here by Ken Jacobson and colleagues, and has been observed for effects on cognitive processes, seizures and ischaemic damage.

中文翻译：

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腺苷受体配体：急性与慢性治疗的差异。


腺苷受体一直是选择性配体在各种治疗领域的潜在用途方面深入研究的目标。咖啡因和茶碱是腺苷受体拮抗剂，在过去三十年中，已经开发了多种针对腺苷受体亚型的选择性激动剂和拮抗剂。腺苷受体配体的治疗用途的复杂性是观察到特定配体的急性施用的效果可能与相同配体的慢性效果截然相反。 Ken Jacobson 及其同事在此讨论了这种“效应倒置”，并观察到了它对认知过程、癫痫发作和缺血性损伤的影响。