The intrinsic resistance of many mycobacterial species to chemotherapy is largely attributable to their impermeable cell wall. The composition of the cell wall of a particular species appears to be influenced by the environmental niche that the species occupies. The complex regulatory and biosynthetic pathways involved in cell wall biosynthesis and construction offer useful chemotherapeutic targets against mycobacteria.

中文翻译：

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分枝杆菌细胞壁成分的药物敏感性和环境适应性。

许多分枝杆菌对化学疗法的内在抗性很大程度上归因于其不可渗透的细胞壁。特定物种的细胞壁组成似乎受该物种所占据的环境环境影响。细胞壁生物合成和构建中涉及的复杂调控和生物合成途径为抗分枝杆菌提供了有用的化学治疗靶标。