Calcium (Ca2+) and cyclic AMP (cAMP) signaling cross talk and synergize to stimulate the cardinal functions of exocrine cells, regulated exocytosis, and fluid and electrolyte secretion. This physiological process requires the organization of the two signaling pathways into complexes at defined cellular domains and close placement. Such domains are formed by membrane contact sites (MCS). This review discusses the basic properties of Ca2+ signaling in exocrine cells, the role of MCS in the organization of cell signaling and in cross talk and synergism between the Ca2+ and cAMP signaling pathways and, finally, the mechanism by which the Ca2+ and cAMP pathways synergize to stimulate epithelial fluid and electrolyte secretion.

中文翻译：

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外分泌细胞中的 Ca2+ 信号传导。

钙 (Ca2+) 和环磷酸腺苷 (cAMP) 信号交叉和协同作用以刺激外分泌细胞的主要功能、调节胞吐作用以及体液和电解质的分泌。这一生理过程需要将两条信号通路组织成特定细胞域的复合物并紧密放置。这些结构域由膜接触位点 (MCS) 形成。这篇综述讨论了外分泌细胞中 Ca2+ 信号传导的基本特性、MCS 在细胞信号传导组织中的作用以及 Ca2+ 和 cAMP 信号通路之间的串扰和协同作用，最后讨论了 Ca2+ 和 cAMP 通路协同作用的机制刺激上皮液和电解质的分泌。