Many physiological processes, including most kidney-related functions, follow specific rhythms tied to a 24-h cycle. This is largely because circadian genes operate in virtually every cell type in the body. In addition, many noncanonical genes have intrinsic circadian rhythms, especially within the liver and kidney. This new level of complexity applies to the control of renal electrolyte excretion. Furthermore, there is growing evidence that paracrine and autocrine factors, especially the endothelin system, are regulated by clock genes. We have known for decades that excretion of electrolytes is dependent on time of day, which could play an important role in fluid volume balance and blood pressure control. Here, we review what is known about the interplay between paracrine and circadian control of electrolyte excretion. The hope is that recognition of paracrine and circadian factors can be considered more deeply in the future when integrating with well-established neuroendocrine control of excretion.

中文翻译：

---

肾脏电解质排泄的昼夜调节：旁分泌因子的作用。

许多生理过程，包括大多数与肾脏有关的功能，都遵循与24小时周期相关的特定节律。这主要是因为生物钟基因实际上在人体的每种细胞类型中起作用。另外，许多非经典基因具有内在的昼夜节律，尤其是在肝脏和肾脏内。这种新的复杂性水平适用于肾脏电解质排泄的控制。此外，越来越多的证据表明旁分泌和自分泌因子，尤其是内皮素系统受时钟基因调控。几十年来，我们知道电解质的排泄取决于一天中的时间，这可能在体液平衡和血压控制中起重要作用。在这里，我们回顾一下有关旁分泌和电解质排泄的昼夜节律控制之间相互作用的知识。