Ti-6Al-4V alloy, as a widely used orthopedic and dental implant, has excellent biocompatibility and machinability. However, its poor corrosion resistance and antibacterial property may lead to tissue inflammation and postoperative infection, which hinders its further development. In this paper, to solve the above problems, copper (Cu) and zinc (Zn) ions were coimplanted into a titanium nitride (TiN) coated Ti-6Al-4V alloy via a plasma immersion ion implantation system (PIII). Then, the structure and composition of Cu/Zn coimplanted TiN (Cu/Zn-TiN-PIII) were characterized by scanning electron microscopy and x-ray photoelectron spectroscopy. Also, the results of the corrosion test, the water contact angles test, and the protein electrophoresis experiment showed that the corrosion resistance, hydrophilicity, and the protein adsorption capacity of Cu/Zn-TiN-PIII were improved simultaneously. In addition, compared with TiN-PIII, Cu/Zn-TiN-PIII promoted both cytocompatibility and the antibacterial property according to L929 cells and Escherichia coli assays in vitro. Therefore, Cu/Zn-TiN-PIII may be a good candidate for orthopedic implants.

中文翻译：

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Cu / Zn共注入TiN对Ti-6Al-4V合金的生物作用。

Ti-6Al-4V合金是一种广泛使用的骨科和牙科植入物，具有出色的生物相容性和可加工性。但是，其较差的耐腐蚀性和抗菌性能可能导致组织发炎和术后感染，从而阻碍了其进一步发展。为了解决上述问题，通过等离子体浸没离子注入系统（PIII）将铜（Cu）和锌（Zn）离子共注入到涂有氮化钛（TiN）的Ti-6Al-4V合金中。然后，通过扫描电子显微镜和X射线光电子能谱表征了Cu / Zn共注入的TiN（Cu / Zn-TiN-PIII）的结构和组成。另外，腐蚀试验，水接触角试验和蛋白质电泳试验的结果表明，耐腐蚀性，亲水性，同时提高了Cu / Zn-TiN-PIII的蛋白质吸附能力。此外，根据L929细胞和体外大肠杆菌试验，与TiN-PIII相比，Cu / Zn-TiN-PIII促进了细胞相容性和抗菌性能。因此，Cu / Zn-TiN-PIII可能是骨科植入物的理想选择。