Performance and safety of materials in contact with living matter are determined by sequential and competitive protein adsorption. However, cause and consequences of these processes remain hard to be generalized and predicted. In a new attempt to address that challenge, the authors compared and analyzed the protein adsorption and displacement on various thoroughly characterized polymer substrates using a combination of surface-sensitive techniques. A multiple linear regression approach was applied to model the dependence of protein adsorption, desorption, and exchange dynamics on protein and surface characteristics. While the analysis confirmed that protein properties primarily govern the observed adsorption and retention phenomena and hydrophobicity as well as surface charge are the most relevant polymer surface properties, the authors have identified several protein-surface combinations that deviate from these patterns and deserve further investigation.

中文翻译：

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蛋白质吸附动力学到聚合物表面的重新探讨-一种多系统方法。

与生物接触的材料的性能和安全性由顺序和竞争性蛋白质吸附决定。但是，这些过程的因果关系仍然难以一概而论。在应对这一挑战的新尝试中，作者使用表面敏感技术的组合，比较并分析了蛋白质在各种经过充分表征的聚合物基质上的吸附和置换。应用了多元线性回归方法来模拟蛋白质吸附，解吸和交换动力学对蛋白质和表面特征的依赖性。分析确认蛋白质性质主要决定着观察到的吸附和保留现象，而疏水性和表面电荷是最相关的聚合物表面性质，