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Multicentric Round Cell Neoplasms and Their Viral Associations in Wild Turkeys (Meleagris gallopavo) in the Southeastern United States.
Veterinary Pathology ( IF 2.3 ) Pub Date : 2019-07-28 , DOI: 10.1177/0300985819864306
Kevin D Niedringhaus 1 , Nicole M Nemeth 1 , Holly S Sellers 2 , Justin D Brown 3 , Heather M A Fenton 1, 4
Affiliation  

Multiple oncogenic viruses, including lymphoproliferative disease virus (LPDV) and reticuloendotheliosis virus (REV), have been detected in wild turkeys (Meleagris gallopavo). The prevalence of infection with these viruses appears to be more common than overt disease; thus, data on the manifestation of associated disease in wild turkeys are scarce. Diagnostic records from wild turkeys submitted to the Southeastern Cooperative Wildlife Disease Study from 1980 to 2017 were reviewed to identify cases of neoplasia. Neoplasia was reported in 59 of 851 (6.9%) wild turkeys submitted. Of the cases of neoplasia tested by polymerase chain reaction, LPDV was detected in 34 of 58 (59%), REV in 10 of 39 (26%), both viruses in 3 of 39 (8%), and no retroviruses detected in 5 of 39 (13%) turkeys. The most common gross lesions observed among turkeys with neoplasms were emaciation (30/40; 75%); nodules in the skin (26/59; 44%), liver (17/59; 29%), or spleen (9/59; 15%); and splenomegaly (14/59; 24%). Microscopically, nodules were composed of pleomorphic round cells with large eccentric nuclei and prominent nucleoli resembling lymphocytes or lymphoblasts (57/59; 97%) except for 2 cases, one of myeloid cell origin and the other with primarily spindloid cells. This study indicates the need to characterize the pathogenesis and potential health threat posed by REV and LPDV to wild turkeys. Experimental infection studies and the development of additional diagnostic tests to confirm the role of retroviruses in lymphoproliferative disease are warranted.

中文翻译:

美国东南部野生火鸡(Meleagris gallopavo)中的多中心圆形细胞肿瘤及其病毒缔合。

在野生火鸡(Meleagris gallopavo)中已发现多种致癌病毒,包括淋巴增生性疾病病毒(LPDV)和网状内皮内皮病病毒(REV)。这些病毒的感染率似乎比明显的疾病更普遍。因此,有关野火鸡中相关疾病表现的数据很少。审查了1980年至2017年提交给东南合作野生动物疾病研究的野生火鸡的诊断记录,以鉴定瘤形成病例。在提交的851只野火鸡中,有59只(6.9%)报道有肿瘤。在通过聚合酶链反应检测的瘤形成病例中,发现58例中的34例(59%)LPDV,39例中的10例REV(26%),39例中的3例病毒(8%)和5例未检测到逆转录病毒39(13%)火鸡。在带有肿瘤的火鸡中,最常见的肉眼可见消瘦(30/40; 75%);皮肤(26/59; 44%),肝脏(17/59; 29%)或脾脏(9/59; 15%)中的结节; 和脾肿大(14/59; 24%)。在显微镜下,结节由多形的圆形细胞组成,具有大的偏心核和突出的核仁,类似于淋巴细胞或成淋巴细胞(57/59; 97%),除了2例,其中一种是髓样细胞起源,而另一例是主要的纺锤体细胞。这项研究表明,需要表征REV和LPDV对野生火鸡的发病机理和潜在的健康威胁。进行实验性感染研究和开发其他诊断测试以证实逆转录病毒在淋巴增生性疾病中的作用是必要的。或脾脏(9/59; 15%);和脾肿大(14/59; 24%)。在显微镜下,结节由多形的圆形细胞组成,具有大的偏心核和突出的核仁,类似于淋巴细胞或成淋巴细胞(57/59; 97%),除了2例,其中一种是髓样细胞起源,而另一例是主要的纺锤体细胞。这项研究表明,需要表征REV和LPDV对野生火鸡的发病机理和潜在的健康威胁。进行实验性感染研究和开发其他诊断测试以证实逆转录病毒在淋巴增生性疾病中的作用是必要的。或脾脏(9/59; 15%);和脾肿大(14/59; 24%)。在显微镜下,结节由多形的圆形细胞组成,具有大的偏心核和突出的核仁,类似于淋巴细胞或成淋巴细胞(57/59; 97%),除了2例,其中一种是髓样细胞起源,而另一例是主要的纺锤体细胞。这项研究表明,需要表征REV和LPDV对野生火鸡的发病机理和潜在的健康威胁。进行实验性感染研究和开发其他诊断测试以证实逆转录病毒在淋巴增生性疾病中的作用是必要的。一种是骨髓细胞起源,另一种主要是纺锤体细胞。这项研究表明,需要表征REV和LPDV对野生火鸡的发病机理和潜在的健康威胁。进行实验性感染研究和开发其他诊断测试以证实逆转录病毒在淋巴增生性疾病中的作用是必要的。一种是骨髓细胞起源,另一种主要是纺锤体细胞。这项研究表明,需要表征REV和LPDV对野生火鸡的发病机理和潜在的健康威胁。进行实验性感染研究和开发其他诊断测试以证实逆转录病毒在淋巴增生性疾病中的作用是必要的。
更新日期:2019-11-01
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