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Locus of Control and Cognition in Older Adults With Type 1 Diabetes: Evidence For Sex Differences From the Study of Longevity in Diabetes (SOLID).
Alzheimer Disease & Associated Disorders ( IF 1.8 ) Pub Date : 2019-10-22 , DOI: 10.1097/wad.0000000000000352
Chloe W Eng 1, 2 , Paola Gilsanz 1 , Mary E Lacy 1, 2 , Michal Schnaider Beeri 3, 4 , Rachel A Whitmer 1, 2, 5
Affiliation  

OBJECTIVE Life expectancy for individuals with type 1 diabetes mellitus (T1DM) has increased recently; however, it is unknown how diabetes care attitudes affect late-life brain health. RESEARCH DESIGN AND METHODS The Study of Longevity in Diabetes (SOLID) consists of 734 older adults with T1DM, reporting diabetes locus of control (dLOC), age of diabetes diagnosis and other demographics, history of hypoglycemic episodes, and depressive symptoms. Global and domain-specific (language, executive function, episodic memory, simple attention) cognitive functioning was assessed at in-person interviews. Cross-sectional associations between dLOC and cognition were estimated using covariate-adjusted linear regression models in pooled and sex-stratified models. RESULTS In pooled analyses, a 1-point increase in dLOC (more internal) was positively associated with global cognition [β=0.05, 95% confidence interval (CI): 0.02, 0.07], language (β=0.04, 95% CI: 0.01, 0.07), and executive function (β=0.04, 95% CI: 0.01, 0.07), but not episodic memory or simple attention. However, in sex-stratified analyses, this effect was seen only in males and not females. CONCLUSIONS In elderly individuals with T1DM, we found associations between dLOC and cognition overall and in men but not women. Underlying sex differences should be considered in future research or interventions on psychosocial characteristics for cognition.

中文翻译:

患有 1 型糖尿病的老年人的控制点和认知:来自糖尿病长寿研究 (SOLID) 的性别差异证据。

目标 1 型糖尿病 (T1DM) 患者的预期寿命最近有所增加;然而,尚不清楚糖尿病护理态度如何影响晚年大脑健康。研究设计和方法 糖尿病长寿研究 (SOLID) 由 734 名患有 T1DM 的老年人组成,他们报告了糖尿病控制点 (dLOC)、糖尿病诊断年龄和其他人口统计数据、低血糖发作史和抑郁症状。在面对面访谈中评估了全球和特定领域(语言、执行功能、情景记忆、简单注意力)的认知功能。dLOC 和认知之间的横断面关联是使用合并和性别分层模型中的协变量调整线性回归模型来估计的。结果 在汇总分析中,dLOC(更多内部)增加 1 点与全局认知呈正相关 [β=0.05, 95% 置信区间 (CI): 0.02, 0.07],语言 (β=0.04, 95% CI: 0.01, 0.07),和执行功能 (β=0.04, 95% CI: 0.01, 0.07),但不是情景记忆或简单注意力。然而,在性别分层分析中,这种影响只出现在男性身上,女性身上看不到。结论 在患有 T1DM 的老年人中,我们发现 dLOC 与总体认知之间存在关联,并且在男性而非女性中存在关联。在未来的认知社会心理特征研究或干预中,应考虑潜在的性别差异。在性别分层分析中,这种影响只出现在男性身上,女性身上看不到。结论 在患有 T1DM 的老年人中,我们发现 dLOC 与总体认知之间存在关联,并且在男性而非女性中存在关联。在未来的认知社会心理特征研究或干预中,应考虑潜在的性别差异。在性别分层分析中,这种影响只出现在男性身上,女性身上看不到。结论 在患有 T1DM 的老年人中,我们发现 dLOC 与总体认知之间存在关联,并且在男性而非女性中存在关联。在未来的认知社会心理特征研究或干预中,应考虑潜在的性别差异。
更新日期:2019-11-01
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