Ankylosing spondylitis (AS) and gout are common inflammatory arthropathies. It had been claimed previously that the two conditions rarely coexist. The aim of this study was to compare the prevalence of gout in a population of AS patients to its prevalence in the general population. To conduct this population-based case-control study, data of adult patients with a physician diagnosis of AS were retrieved from the database of the largest health-care provider organization in Israel, Clalit Health Services. For each patient with AS, five age- and sex-matched subjects without AS were randomly selected from the same database. Different parameters including the existence of gout, hypertension, body mass index, socioeconomic status, and smoking were evaluated in both the AS and the control groups. The study included 3763 patients with AS and 19,214 controls. The proportion of gout in the AS group was higher than in the control group: 73 subjects in the AS group had gout, while only 107 subjects in the non-AS group had gout (1.94% and 0.56%, respectively, OR 3.53, P < 0.001). Logistic regression adjusting for possible confounding variables found that AS was independently associated with gout (OR 1.41, P = 0.037). Our study suggests that gout is not less common in AS patients in comparison with the general population, and that it might even be more common in AS patients.

中文翻译：

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强直性脊柱炎患者痛风并存：一项病例对照研究。

强直性脊柱炎（AS）和痛风是常见的炎症性关节病。以前有人声称这两种情况很少共存。这项研究的目的是比较痛风在AS患者中的患病率与普通人群中的患病率。为了进行这项基于人群的病例对照研究，从以色列最大的卫生保健提供者组织Clalit Health Services的数据库中检索出患有AS诊断为AS的成年患者的数据。对于每位患有AS的患者，均从同一数据库中随机选择了五名年龄和性别匹配的无AS的受试者。在AS和对照组中评估了不同的参数，包括痛风的存在，高血压，体重指数，社会经济状况和吸烟。该研究包括3763例AS患者和19例，214个控件。AS组中痛风的比例高于对照组：AS组中73名受试者患有痛风，而非AS组中只有107名受试者患有痛风（分别为1.94％和0.56％，OR 3.53，P <0.001）。对可能的混杂变量进行逻辑回归调整后，发现AS与痛风独立相关（OR 1.41，P = 0.037）。我们的研究表明，与普通人群相比，痛风在AS患者中并不罕见，甚至在AS患者中更常见。对可能的混杂变量进行逻辑回归调整后，发现AS与痛风独立相关（OR 1.41，P = 0.037）。我们的研究表明，与普通人群相比，痛风在AS患者中并非不常见，甚至在AS患者中更常见。对可能的混杂变量进行逻辑回归调整后，发现AS与痛风独立相关（OR 1.41，P = 0.037）。我们的研究表明，与普通人群相比，痛风在AS患者中并不罕见，甚至在AS患者中更常见。