This study investigated the relationship between alcohol consumption with alcohol-induced facial flushing response and rheumatoid factor (RF) in adult men. The cohort comprised 1675 men who underwent a general medical check-up between July 2016 and June 2017, including 355 non-drinkers, 498 flushers, and 822 non-flushers. One drink was defined as 14 g of alcohol. RF was considered negative if the level was less than 18 IU/mL and positive if the level was greater than 18 IU/mL. Logistic regression analyses were used. Compared to non-drinkers, the odds ratio for a positive RF among non-flushers was 0.92 (95% confidence interval [CI], 0.37-2.29) for those with an average alcohol consumption of ≤4 drinks per week, 1.64 (95% CI, 0.67-3.98) for those consuming more than 4 drinks per week but fewer than or equal to 8 drinks per week, and 1.17 (95% CI, 0.55-2.50) for those consuming more than 8 drinks per week; the differences were not statistically significant. Compared to non-drinkers, flushers also had a non-significant odds ratio for positive RF of 1.26 (95% CI, 0.54-2.90) among those with an average alcohol consumption of ≤4 drinks per week. However, flushers showed a significantly higher odds ratio for a positive RF of 3.12 (95% CI, 1.18-8.24) among those consuming more than 4 but fewer than or equal to 8 drinks per week, and 3.27 (95% CI, 1.42-7.52) among those consuming more than 8 drinks per week. Additionally, flushers consuming more than 8 drinks per week were associated with significantly higher rates of positive RF than non-flushers (odds ratio, 2.38; 95% CI, 1.05-5.17). Our study revealed that flushers consuming more than 4 drinks per week showed a higher probability of positive RF than non-drinkers. Furthermore, flushers consuming more than 8 drinks per week had a higher probability of positive RF than non-flushers. Our results strongly indicate that the average weekly alcohol consumption level and the presence or absence of flushing should be considered when interpreting the results of RF examinations in healthy men.

中文翻译：

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饮酒和类风湿因子（RF）与酒精引起的面部潮红反应之间的关系。

这项研究调查了成年男性饮酒与酒精引起的面部潮红反应和类风湿因子（RF）之间的关系。该队列包括1675名男性，他们在2016年7月至2017年6月之间接受了常规医疗检查，其中包括355名非饮酒者，498名冲洗者和822名非冲洗者。一瓶饮料定义为14克酒精。如果水平小于18 IU / mL，则RF被认为是阴性的；如果水平大于18 IU / mL，则RF被认为是阳性。使用逻辑回归分析。与非饮酒者相比，每周平均饮酒量≤4的饮酒者与非饮酒者中RF阳性的比值比是0.92（95％置信区间[CI]，0.37-2.29），是1.64（95％）每周饮用4杯以上但每周少于或等于8杯的消费者的CI（0.67-3.98）和1.17（95％CI，0。（55-2.50）：每周消费8杯以上的饮料；差异无统计学意义。与非饮水机相比，在每周平均饮酒量≤4的饮水机中，冲厕者的正RF的比值比也无统计学意义，为1.26（95％CI，0.54-2.90）。但是，冲洗者的正RF值为3.12（95％CI，1.18-8.24），每周消费4杯以上但少于或等于8杯，而3.27（95％CI，1.42- 7.52）那些每周消费超过8杯酒的人。此外，冲厕者每周消费8杯以上的饮料，其RF阳性率显着高于非冲厕者（优势比，2.38； 95％CI，1.05-5.17）。我们的研究表明，与不喝水的人相比，每周喝超过4杯饮料的冲水者出现RF的可能性更高。此外，与非冲洗器相比，每周消耗超过8杯饮料的冲洗器具有较高的RF阳性可能性。我们的结果强烈表明，在解释健康男性的RF检查结果时，应考虑平均每周饮酒量和是否出现潮红。