Screening for pancreatic cancer (PC) in high-risk groups aimed to detect early cancers is currently done only in the research setting, and data on psychological outcomes of screening in these populations is scarce. To determine the psychological impact of a national Australian pancreatic screening program, a prospective study was conducted using validated psychological measures: impact of events scale (IES), psychological consequences questionnaire (PCQ) and the cancer worry scale. Measures were administered at baseline, 1-month and at 1-year post-enrolment and correlations with abnormal endoscopic ultrasound (EUS) results were calculated. Over a 6-year period, 102 participants were recruited to the screening program. Thirty-nine patients (38.2%) had an abnormal endoscopic ultrasound, and two patients (2.0%) were diagnosed with PC and two with other malignancies. Those with a personal history of cancer or a positive BRCA2 mutation demonstrated significantly increased worry about developing other types of cancer at baseline (p < 0.01). Irrespective of EUS result, there was a significant decrease of total IES score at 1 year (Z = − 2.0, p = 0.041). In patients with abnormal EUS results, there was a decrease in the total IES score at 1 year (Z = − 2.5, p = 0.011). In participants deemed to be most distressed at baseline based on their negative PCQ score, there was a significant decrease of the total PCQ (Z = − 3.2, p = 0.001), emotional (Z = − 3.0, p = 0.001), social (Z = 3.0, p = 0.001) and physical (Z = − 2.8, p = 0.002) subscale at 1-year post-intervention. This study provides evidence of the long-term psychological benefits of PC screening in high-risk patients. There was no negative impact of screening in the short-term and the positive benefits appeared at 1-year post-intervention irrespective of screening result.

中文翻译：

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澳大利亚胰腺癌筛查计划的长期积极心理结果。

目前仅在研究环境中对旨在发现早期癌症的高危人群进行胰腺癌（PC）筛查，而在这些人群中进行筛查的心理结果方面的数据很少。为了确定澳大利亚全国胰腺筛查计划的心理影响，使用经过验证的心理测量方法进行了一项前瞻性研究：事件影响量表（IES），心理后果问卷（PCQ）和癌症忧虑量表。在基线，入组后1个月和1年时进行测量，并计算与异常内镜超声（EUS）结果的相关性。在6年的时间里，有102名参与者被招募入选。三十九例（38.2％）内镜超声检查异常，两名患者（2。0％）被诊断为PC，另外两个则被诊断为其他恶性肿瘤。具有个人癌症病史或BRCA2突变为阳性的人表明，对在基线发展为其他类型癌症的担忧显着增加（p  <0.01）。无论EUS结果如何，在1年时总IES得分均显着降低（Z = − 2.0，p  = 0.041）。在EUS结果异常的患者中，一年的总IES评分降低（Z = − 2.5，p  = 0.011）。在基于其负面PCQ分数被认为在基线时最受困扰的参与者中，总PCQ（Z = − 3.2，p  = 0.001），情感（Z = − 3.0，p  = 0.001），社交（ Z = 3.0，p  = 0.001）和物理（Z = − 2.8，p = 0.002）干预后1年的子量表。这项研究为高危患者进行PC筛查提供了长期的心理益处的证据。短期内没有筛查的负面影响，干预后的1年无论筛查结果如何，都显示出积极的益处。