Novel strategies are needed for combating Staphylococcus aureus biofilm in vascular graft infections. We investigated the in vitro activity of bacteriophage endolysin HY-133, daptomycin and rifampin against S. aureus attached to vascular graft surface. Daptomycin showed rapid bactericidal effect on surface-associated S. aureus, while the activity of HY-133 on graft surface-adherent cells was moderate and rifampin did not achieve bactericidal effect. Even in the highest concentrations, all antimicrobials used failed in a complete eradication of the surface-adherent bacteria.

中文翻译：

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噬菌体溶血素HY-133对附着在血管移植物表面的金黄色葡萄球菌的体外体外活性比较。

需要新的策略来对抗血管移植物感染中的金黄色葡萄球菌生物膜。我们调查了噬菌体溶血素HY-133，达托霉素和利福平对附着在血管移植物表面的金黄色葡萄球菌的体外活性。达托霉素对与表面相关的金黄色葡萄球菌具有快速杀菌作用，而HY-133对移植物表面粘附细胞的活性中等，而利福平没有达到杀菌作用。即使以最高浓度使用，所有使用的抗菌剂也无法完全清除表面附着的细菌。