When a contact lens is in contact with the eyelid and the cornea, tear proteins start to be accumulated on the lens and may subsequently undergo conformational changes. Protein adsorption or conformational changes on the lens may lead to discomfort, red eye, or even inflammatory reactions. Although measuring the friction coefficient of contact lens has been linked to comfort degree in vivo, there is not much research about the effects of tear protein deposition on the friction coefficient of the contact lens. Therefore, we investigated the friction coefficient of three distinct materials of contact lenses in two different lysosomal concentrations. We also studied lysozyme deposition on the lens without the influence of friction. The results demonstrated that although the amount of lysozyme deposition was high on all the materials we tested, it was not corresponded to higher friction coefficient. In addition, we investigated the effect of the contact lens care solution we developed on friction coefficient and lysozyme deposition of three different materials of contact lenses. The results showed that the care solution could reduce the increased friction coefficient caused by high lysosomal concentration. Therefore, we proposed a potential mechanism of why lysosomal deposition may result in high friction coefficient for certain types of hydrogel contact lenses.

中文翻译：

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溶酶体沉积对水凝胶隐形眼镜摩擦系数的影响。

当隐形眼镜与眼睑和角膜接触时，眼泪蛋白开始在眼镜上积聚，并随后可能发生构象变化。蛋白质在晶状体上的吸附或构象变化可能导致不适，红眼甚至是炎症反应。尽管测量隐形眼镜的摩擦系数与体内舒适度有关，但是关于泪液蛋白沉积对隐形眼镜的摩擦系数的影响的研究还很少。因此，我们研究了两种不同溶酶体浓度下三种不同材料的隐形眼镜的摩擦系数。我们还研究了溶菌酶在晶状体上的沉积，没有摩擦的影响。结果表明，尽管在我们测试的所有材料上溶菌酶的沉积量都很高，它并不对应于更高的摩擦系数。此外，我们研究了我们开发的隐形眼镜护理液对三种不同隐形眼镜材料的摩擦系数和溶菌酶沉积的影响。结果表明，该护理液可以降低高溶酶体浓度引起的摩擦系数的增加。因此，我们提出了为什么溶酶体沉积可能导致某些类型的水凝胶隐形眼镜的高摩擦系数的潜在机制。结果表明，该护理液可以降低高溶酶体浓度引起的摩擦系数的增加。因此，我们提出了为什么溶酶体沉积可能导致某些类型的水凝胶隐形眼镜的高摩擦系数的潜在机制。结果表明，该护理液可以降低高溶酶体浓度引起的摩擦系数的增加。因此，我们提出了为什么溶酶体沉积可能导致某些类型的水凝胶隐形眼镜的高摩擦系数的潜在机制。