The use of leaded gasoline adversely affects cardiovascular, nervous, and immune systems. Study projects to rule out different variables of prognostic importance in lead-exposed subjects. A total of 317 traffic wardens with 5 years of outdoor experience and Hb levels < 10 µg/dl, and 100 traffic wardens with indoor duties were substituted in two groups. Levels of vitamins, cytokines, lead, iron, minerals, oxidative stress, and lipid peroxidation were estimated with help of their standard ELISA and spectrophotometric methods respectively. The present study show increased levels of lead in subjects (29.8 ± 3.8 vs. 1.5 ± 0.2 µg/dl) that may be involved in increasing oxidative stress, i.e., levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and isoprostanes were increased in subjects (4.6 ± 0.5, 4.3 ± 0.6 and 37.2 ± 5.1). Moreover, levels of antioxidants, i.e., superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), were decreased. It also exhibits reduced levels of different enzymes in anemic traffic wardens. Current study concludes that wardens exposed to environmental lead are more susceptible to develop cardiovascular and neurological disorders. It shows that toxicity of lead maybe responsible for redox imbalance and production of proinflammatory cytokines. Thus, early detection of these biomarkers may help to reduce lead toxicity and it also may help to control the dilemma of uncontrolled environmental pollution by implicating strict actions against substandard gasoline.

中文翻译：

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铅暴露受试者预后重要性的生理生化变量的含义。

使用含铅汽油会对心血管，神经和免疫系统产生不利影响。研究项目排除了铅暴露受试者的预后重要性的不同变量。两组共替换了317位具有5年户外经验和Hb水平<10 µg / dl的交通管理员，以及100位具有室内职责的交通管理员。维生素，细胞因子，铅，铁，矿物质，氧化应激和脂质过氧化的水平分别通过其标准ELISA和分光光度法进行估算。本研究表明，受试者体内铅水平的升高（29.8±3.8 vs. 1.5±0.2 µg / dl）可能与氧化应激的增加有关，即丙二醛（MDA），4-羟基壬醛（4-HNE），和异前列腺素增加的受试者（4.6±0.5，4.3±0.6和37.2±5.1）。此外，抗氧化剂的水平降低，即超氧化物歧化酶（SOD），谷胱甘肽（GSH）和过氧化氢酶（CAT）。在贫血的交通管理员中，它还表现出不同酶水平的降低。当前的研究得出的结论是，暴露于环境铅的病房更容易发展为心血管疾病和神经疾病。这表明铅的毒性可能是氧化还原失衡和促炎细胞因子产生的原因。因此，尽早发现这些生物标记物可能有助于降低铅的毒性，并且还可以通过对不合格汽油采取严格的措施来控制不受控制的环境污染的困境。当前的研究得出的结论是，暴露于环境铅的病房更容易发展为心血管疾病和神经疾病。这表明铅的毒性可能是氧化还原失衡和促炎细胞因子产生的原因。因此，尽早发现这些生物标记物可能有助于降低铅的毒性，并且还可以通过对不合格汽油采取严格的措施来控制不受控制的环境污染的困境。当前的研究得出的结论是，暴露于环境铅的病房更容易发展为心血管疾病和神经疾病。这表明铅的毒性可能是氧化还原失衡和促炎细胞因子产生的原因。因此，尽早发现这些生物标记物可能有助于降低铅的毒性，并且还可以通过对不合格汽油采取严格的措施来控制不受控制的环境污染的困境。