The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in the digestive system. Abnormal BMP signaling has also been associated with disease initiation and progression in the gastrointestinal (GI) tract and associated organs. Recent studies using animal models, tissue organoids, and human pluripotent stem cells have significantly expanded our understanding of the roles played by BMPs in the development and homeostasis of GI organs. It is clear that BMP signaling regulates GI function and disease progression that involve stem/progenitor cells and inflammation in a tissue-specific manner. In this review we discuss these new findings with a focus on the esophagus, stomach, and intestine.

中文翻译：

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BMP 信号在发育、干细胞和胃肠道疾病中的作用。

骨形态发生蛋白 (BMP) 通路对于消化系统中多个器官的形态发生至关重要。异常的 BMP 信号也与胃肠道 (GI) 道和相关器官的疾病发生和进展有关。最近使用动物模型、组织类器官和人类多能干细胞的研究显着扩展了我们对 BMP 在胃肠道器官发育和稳态中所起作用的理解。很明显，BMP 信号以组织特异性方式调节涉及干细胞/祖细胞和炎症的 GI 功能和疾病进展。在这篇综述中，我们将重点讨论食道、胃和肠的这些新发现。