Conducting polymers (CPs) is one of intelligent biomaterials with the specific properties of reversible redox states, which have a significant effects on the cell behaviors and nerve tissue regeneration. However, the effects of CPs with different electrical conductivity on the behaviors of nerve cells are rarely reported. Therefore, a kind of Poly(3‐hexylthiophene) (P3HT) with certain molecular weight is synthesized by Kumada catalyst transfer polymerization (KCTP) method and employed to prepare bioabsorbable and electroactive intelligent composites of Poly(3‐hexylthiophene)/Poly(glycolide‐lactide) (P3HT/PLGA). FeCl₃ doping electroactive membranes with different electrical conductivities are prepared to investigate the cell behaviors. On the substrate with higher electrical conductivity, the proliferation of rat adrenal pheochromocytoma cells (PC12 cells) is significantly promoted and neurite length is increased obviously. In particular, the most significant improvements are the neuron gene expression of Synapsin 1 and microtubule‐associated protein 2 (MAP2) by the composites with high conductivity. These results suggest that P3HT/PLGA with suitable electrical conductivity have a positive role in promoting neural growth and differentiation, which is promising for advancing potential application of nerve repair and regeneration.

中文翻译：

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FeCl3掺杂的P3HT / PLGA电活性复合材料具有可调节的电导率，可潜在地应用于神经组织工程。

导电聚合物（CPs）是具有可逆氧化还原状态特定特性的智能生物材料之一，其对细胞行为和神经组织再生具有重大影响。然而，很少报道具有不同电导率的CP对神经细胞行为的影响。因此，通过熊田催化剂转移聚合（KCTP）方法合成了一种具有一定分子量的聚（3-己基噻吩）（P3HT），并用于制备聚（3-己基噻吩）/聚乙交酯的生物可吸收和电活性智能复合材料。丙交酯（P3HT / PLGA）。的FeCl ₃制备具有不同电导率的掺杂电活性膜以研究细胞行为。在具有较高电导率的基质上，大鼠肾上腺嗜铬细胞瘤细胞（PC12细胞）的增殖得到明显促进，神经突长度明显增加。特别是，最显着的改善是高电导率复合材料对突触蛋白1和微管相关蛋白2（MAP2）的神经元基因表达。这些结果表明，具有合适电导率的P3HT / PLGA在促进神经生长和分化中具有积极作用，这有望促进神经修复和再生的潜在应用。