The respiratory system has ideal tissue structure and cell types for efficient gas exchange to intake oxygen and release carbon dioxide. This complex system develops through orchestrated intercellular signaling among various cell types, such as club, ciliated, basal, neuroendocrine, AT1, AT2, endothelial, and smooth muscle cells. Notch signaling is a highly conserved cell-cell signaling pathway ideally suited for very short-range cellular communication because Notch signals are transmitted by direct contact with an adjacent cell. Enthusiastic efforts by Notch researchers over the last two decades have led to the identification of critical roles of this signaling pathway during development, homeostasis, and regeneration of the respiratory system. The dysregulation of Notch signaling results in a wide range of respiratory diseases such as pulmonary artery hypertension (PAH), chronic obstructive pulmonary disease (COPD), interstitial pulmonary fibrosis (IPF), and lung cancer. Thus, a deep understanding of the biological functions of Notch signaling will help identify novel treatment targets in various respiratory diseases.

中文翻译：

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在哺乳动物的呼吸系统，特别是气管和肺中，Notch信号正在发育，体内平衡，再生和疾病中。

呼吸系统具有理想的组织结构和细胞类型，可进行有效的气体交换以吸收氧气并释放二氧化碳。这个复杂的系统通过各种细胞类型（例如俱乐部，纤毛，基底，神经内分泌，AT1，AT2，内皮和平滑肌细胞）之间精心策划的细胞间信号传导而发展。Notch信号是高度保守的细胞-细胞信号通路，非常适合于非常短距离的蜂窝通信，因为Notch信号是通过与相邻细胞直接接触来传输的。在过去的二十年中，Notch研究人员的热情努力已经确定了该信号通路在呼吸系统发育，体内平衡和再生过程中的关键作用。Notch信号的失调导致多种呼吸系统疾病，例如肺动脉高压（PAH），慢性阻塞性肺疾病（COPD），间质性肺纤维化（IPF）和肺癌。因此，深入了解Notch信号传导的生物学功能将有助于确定各种呼吸系统疾病的新型治疗靶点。