Skin‐derived precursors (SKPs) have been described as multipotent dermal precursors. Here, we provide a review of the breadth and depth of scientific literature and studies regarding SKPs, accounting for a large number of scientific publications. Interestingly, these progenitors can be isolated from embryonic and adult skin, as well as from a population of dermal cells cultured in vitro in monolayer. Gathering information from different authors, this review explores different aspects of the SKP theme, such as the potential distinct origins of SKPs in rodents and in humans, and also their ability to differentiate in vitro and in vivo into multiple lineages of different progeny. This remarkable capacity makes SKPs an interesting endogenous source of precursors to explore in the framework of experimental and therapeutic applications in different domains. SKPs are not only involved in the skin’s dermal maintenance and support as well as wound healing, but also in hair follicle morphogenesis. This review points out the interests of future researches on SKPs for innovative perspectives that may be helpful in many different types of scientific and medical domains.

中文翻译：

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皮肤来源的前体的多潜能：应用于皮肤和其他组织的再生。

皮肤来源的前体（SKP）被描述为多能的皮肤前体。在这里，我们提供了有关科学文献和有关SKP的研究的广度和深度的综述，其中包括大量的科学出版物。有趣的是，这些祖细胞可以从胚胎和成年皮肤中分离，也可以从体外单层培养的真皮细胞中分离出来。收集来自不同作者的信息，本综述探讨了SKP主题的不同方面，例如，啮齿动物和人类潜在的SKP独特来源，以及它们在体外和体内分化的能力分成不同后代的多个血统。这种非凡的能力使SKP成为有趣的内源性前体来源，可以在不同领域的实验和治疗应用框架中进行探索。SKP不仅参与皮肤的真皮维护和支持以及伤口愈合，还参与毛囊的形态发生。这篇评论指出了关于SKPs的未来研究的兴趣，这些创新观点可能对许多不同类型的科学和医学领域都有帮助。