Purpose

Chronic ocular graft-versus-host disease (GVHD) is a long-term complication after hematopoietic stem cell transplantation (HSCT) and leads to irreversible visual morbidity due to severe ocular surface impairments including visual disfunction. However, knowledge about the optical function in chronic ocular GVHD is limited because it is difficult to assess quantitative optical function objectively. The development of anterior segment optical coherence tomography has allowed objective quantification of optical function by evaluating corneal higher-order aberrations (HOAs). Therefore, we applied this quantification in chronic ocular GVHD patients and verified the correlation between corneal HOAs and visual acuity.

Methods

We retrospectively reviewed chronic ocular GVHD patients and the recipients after HSCT. Then, analyzed the relationship between visual function and the severity of chronic ocular GVHD.

Results

The eyes of patients with chronic ocular GVHD had higher corneal HOAs than those of non-GVHD patients (HOAs; 0.481 ± 0.306 vs 0.254 ± 0.084, and 0.917 ± 0.609 vs 0.529 ± 0.130. P < 0.001, and 0.002. 4-mm and 6-mm diameters respectively. Corneal HOAs were correlated with the severity of chronic ocular GVHD (r = 0.436. P < 0.001). Moreover, corneal HOAs were correlated with visual acuity, especially in eyes with severe chronic ocular GVHD cases (HOAs; 4-mm r = 0.636. P = 0.036. Total 6-mm r = 0.871. P =<0.001).

Conclusions

We succeed to assess the objective value in the optical function of the chronic ocular GVHD. Quantification of corneal HOAs could be an objective evaluation to assess optical function in eyes with chronic ocular GVHD.

中文翻译：

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慢性眼移植物抗宿主病眼的角膜高阶像差。

目的

慢性眼移植物抗宿主病（GVHD）是造血干细胞移植（HSCT）后的长期并发症，由于严重的眼表功能障碍（包括视力障碍）而导致不可逆的视觉发病率。但是，由于很难客观地评估定量的光学功能，因此有关慢性眼GVHD的光学功能的知识有限。前段光学相干断层扫描技术的发展已允许通过评估角膜高阶像差（HOA）来客观量化光学功能。因此，我们将这种量化应用于慢性眼部GVHD患者，并验证了角膜HOA与视敏度之间的相关性。

方法

我们回顾性研究了慢性眼GVHD患者和HSCT后的接受者。然后，分析了视觉功能与慢性眼GVHD严重程度之间的关系。

结果

慢性眼GVHD患者的眼角膜HOA高于非GVHD患者（HOA; 0.481±0.306 vs 0.254±0.084，0.917±0.609 vs 0.529±0.130。P <0.001，0.002。4-mm和直径分别为6mm，角膜HOA与慢性眼GVHD的严重程度相关（r = 0.436。P <0.001）。此外，角膜HOA与视力相关，特别是在患有严重慢性眼GVHD病例的眼中（HOA; 4） -mm r = 0.636。P = 0.036。总计6 mm r = 0.871。P = <0.001）。

结论

我们成功地评估了慢性眼GVHD的光学功能的客观价值。定量角膜HOA可能是评估慢性眼GVHD眼睛光学功能的客观评估。