The heritability and parent-of-origin effect hypotheses for chronic diseases can be evaluated by estimating and conducting inference about the parameters that measure the within-family dependences in disease onset times. We model the within-family associations in these times using a Gaussian copula whose correlation matrix accommodates the different pairwise family relationships. We derive score-type statistics to test the heritability and parent-of-origin effect hypotheses when the families selection protocol induces a sampling bias. We illustrate the use of the developed methods through an application to a motivating family study in Psoriatic arthritis and provide strong evidence of excessive paternal transmission of risk. This article is protected by copyright. All rights reserved.

中文翻译：

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在偏倚抽样下测试银屑病关节炎发病年龄的遗传力和亲本假设

慢性病的遗传力和亲本效应假设可以通过估计和推断测量疾病发作时间的家庭内依赖性的参数来评估。我们使用高斯 copula 对这些时期的家庭内关联进行建模，其相关矩阵适应不同的成对家庭关系。当家庭选择协议引起抽样偏差时，我们推导出分数类型统计数据来测试遗传力和亲本效应假设。我们通过应用于银屑病关节炎的激励性家庭研究来说明所开发方法的使用，并提供了父亲过度风险传递的有力证据。本文受版权保护。保留所有权利。