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The evaluation of the repeatability of the 13C-ketoisocaproate breath test for assessing hepatic mitochondrial function
Isotopes in Environmental and Health Studies ( IF 1.1 ) Pub Date : 2019-03-04 , DOI: 10.1080/10256016.2019.1588265
Paul R Afolabi 1, 2 , Eleonora Scorletti 1, 2, 3 , Philip C Calder 1, 2 , Christopher D Byrne 1, 2
Affiliation  

ABSTRACT The 13C-ketoisocaproate (13C-KICA) breath test (BT) has been recently proposed as a non-invasive test for assessing hepatic mitochondrial function. Results of the 13C-KICA BT can be expressed as different parameters. However, the best parameter for expressing the 13C-KICA BT result is uncertain which hinders use of the BT in routine clinical practice. We have investigated the repeatability of different parameters of 13C-KICA BT. Thirteen healthy adult subjects (5 men and 8 women) underwent a 13C-KICA BT on two occasions separated by a gap of approximately 30 days. There were no significant differences between the repeated measurements for all the test parameters over 30 days. Furthermore, the Bland Altman statistics showed no fixed or proportional bias for any of the test parameters. The cumulative 13C-dose enrichment over 60 min had the lowest within-subject variability of 12% compared to all other test parameters. The cumulative 13C-dose enrichment over 60 min could be a very useful parameter for the 13C-KICA BT to detect impaired hepatic mitochondrial function in patients with chronic liver diseases.

中文翻译:

13C-酮异己酸呼气试验评估肝线粒体功能的可重复性评价

摘要 13C-酮异己酸盐 (13C-KICA) 呼气试验 (BT) 最近被提议作为评估肝线粒体功能的非侵入性测试。13C-KICA BT 的结果可以表示为不同的参数。然而,表达 13C-KICA BT 结果的最佳参数是不确定的,这阻碍了 BT 在常规临床实践中的使用。我们研究了 13C-KICA BT 不同参数的可重复性。13 名健康成年受试者(5 名男性和 8 名女性)在间隔大约 30 天的两次间隔中接受了 13C-KICA BT。30 天内所有测试参数的重复测量之间没有显着差异。此外,Bland Altman 统计数据显示任何测试参数都没有固定或成比例的偏差。与所有其他测试参数相比,60 分钟内累积的 13C 剂量富集具有 12% 的最低受试者内变异性。60 分钟内累积的 13C 剂量富集可能是 13C-KICA BT 检测慢性肝病患者肝线粒体功能受损的非常有用的参数。
更新日期:2019-03-04
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