Phosphatidylserine recognition receptors are a highly diverse set of receptors grouped by their ability to recognize the 'eat-me' signal phosphatidylserine on apoptotic cells. Most of the phosphatidylserine recognition receptors dampen inflammation by inducing the production of anti-inflammatory mediators during the phagocytosis of apoptotic corpses. However, many phosphatidylserine receptors are also capable of recognizing other ligands, with some receptors being categorized as scavenger receptors. It is now appreciated that these receptors can elicit different downstream events for particular ligands. Therefore, how phosphatidylserine recognition receptors mediate specific signals during recognition of apoptotic cells versus other ligands, and how this might help regulate the inflammatory state of a tissue is an important question that is not fully understood. Here, we revisit the work on signaling downstream of the phosphatidylserine recognition receptor BAI1, and evaluate how these and other signaling modules mediate signaling downstream from other receptors, including Stabilin-2, MerTK, and αvβ5. We also propose the concept that phosphatidylserine recognition receptors could be viewed as a subset of scavenger receptors that are capable of eliciting anti-inflammatory responses to apoptotic cells.

中文翻译：

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凋亡细胞识别受体和清除剂受体。

磷脂酰丝氨酸识别受体是一组高度多样化的受体，按其识别凋亡细胞上“ eat-me”信号磷脂酰丝氨酸的能力分组。大多数磷脂酰丝氨酸识别受体通过在凋亡小体吞噬过程中诱导产生抗炎介质来减轻炎症。但是，许多磷脂酰丝氨酸受体也能够识别其他配体，其中一些受体被归类为清除剂受体。现在认识到这些受体可以引起特定配体的不同下游事件。因此，在识别凋亡细胞与其他配体的过程中，磷脂酰丝氨酸识别受体如何介导特定信号，以及如何帮助调节组织的炎症状态是一个尚未完全理解的重要问题。在这里，我们重新审视磷脂酰丝氨酸识别受体BAI1下游信号的工作，并评估这些信号模块和其他信号模块如何介导其他受体（包括Stabilin-2，MerTK和αvβ5）下游的信号。我们还提出了这样的概念，磷脂酰丝氨酸识别受体可以看作是清道夫受体的子集，其能够引起对凋亡细胞的抗炎反应。