Abstract Objective: A cognitive neuroscience perspective seeks to understand behavior, in this case the comorbidity of cannabis abuse and conduct disorder/conduct problems, in terms of dysfunction in cognitive processes underpinned by neural processes. The goal of this review is to articulate a cognitive neuroscience account of this comorbidity. Methods: Literature on the following issues will be reviewed: (i) the longitudinal relationship between cannabis abuse and conduct disorder/conduct problems (CD/CP); (ii) the extent to which there are genetic and environmental (specifically maltreatment) factors that underpin this relationship; (iii) forms of neurocognitive function that are reported dysfunctional in CD/CP and also, when dysfunctional, appear to be risk factors for future cannabis abuse; and (iv) the extent to which cannabis abuse may further compromise these systems leading to increased future abuse and greater conduct problems. Results: CD/CP typically predate cannabis abuse. There appear to be shared genetic factors that contribute to the relationship between CD/CP and cannabis abuse. Moreover, trauma exposure increases risk for both cannabis abuse and CP/CD. One form of neurocognitive dysfunction, response disinhibition, that likely exacerbates the symptomatology of many individuals with CD also appears to increase the risk for cannabis abuse. The literature with respect to other forms of neurocognitive dysfunction remains inconclusive. Conclusions: Based on the literature, a causal model of the comorbidity of cannabis abuse and CD/CP is developed.

中文翻译：

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从认知神经科学的角度模拟大麻滥用和行为障碍/行为问题的共病

摘要 目的：认知神经科学的观点试图从神经过程支持的认知过程功能障碍的角度来理解行为，在这种情况下是大麻滥用和品行障碍/行为问题的共病。本综述的目的是阐明这种合并症的认知神经科学。方法：将审查有关以下问题的文献：(i) 大麻滥用与品行障碍/品行问题 (CD/CP) 之间的纵向关系；(ii) 支持这种关系的遗传和环境（特别是虐待）因素的程度；(iii) 在 CD/CP 中报告功能失调的神经认知功能形式，并且当功能失调时，似乎是未来大麻滥用的危险因素；(iv) 大麻滥用可能进一步损害这些系统的程度，导致未来滥用增加和行为问题更大。结果：CD/CP 通常早于大麻滥用。似乎存在共同的遗传因素导致 CD/CP 与大麻滥用之间的关系。此外，创伤暴露增加了大麻滥用和 CP/CD 的风险。神经认知功能障碍的一种形式，即反应解除抑制，可能会加剧许多 CD 患者的症状，也似乎会增加滥用大麻的风险。关于其他形式的神经认知功能障碍的文献仍然没有定论。结论：根据文献，开发了大麻滥用和 CD/CP 合并症的因果模型。