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Reorganization of Large-Scale Functional Networks During Low-Frequency Electrical Stimulation of the Cortical Surface
International Journal of Neural Systems ( IF 6.6 ) Pub Date : 2019-07-29 , DOI: 10.1142/s0129065719500229
Bálint File 1, 2 , Tibor Nánási 1, 3, 4 , Emília Tóth 5 , Virág Bokodi 1, 6 , Brigitta Tóth 3 , Boglárka Hajnal 7 , Zsófia Kardos 3 , László Entz 6 , Loránd Erőss 6 , István Ulbert 1, 3 , Dániel Fabó 7
Affiliation  

We investigated the functional network reorganization caused by low-frequency electrical stimulation (LFES) of human brain cortical surface. Intracranial EEG data from subdural grid positions were analyzed in 16 pre-surgery epileptic patients. LFES was performed by injecting current pulses (10[Formula: see text]mA, 0.2[Formula: see text]ms pulse width, 0.5[Formula: see text]Hz, 25 trials) into all adjacent electrode contacts. Dynamic functional connectivity analysis was carried out on two frequency bands (low: 1–4[Formula: see text]Hz; high: 10–40[Formula: see text]Hz) to investigate the early, high frequency and late, low frequency responses elicited by the stimulation. The centralization increased in early compared to late responses, suggesting a more prominent role of direct neural links between primarily activated areas and distant brain regions. Injecting the current into the seizure onset zone (SOZ) evoked a more integrated functional topology during the early (N1) period of the response, whereas during the late (N2) period — regardless of the stimulation site — the connectedness of the SOZ was elevated compared to the non-SOZ tissue. The abnormal behavior of the epileptic sub-network during both part of the responses supports the idea of the pathogenic role of impaired inhibition and excitation mechanisms in epilepsy.

中文翻译:

皮质表面低频电刺激过程中大规模功能网络的重组

我们研究了由人脑皮质表面的低频电刺激 (LFES) 引起的功能网络重组。对 16 名术前癫痫患者的硬膜下网格位置的颅内脑电图数据进行了分析。LFES 是通过向所有相邻电极触点注入电流脉冲(10[公式:见文本]mA、0.2[公式:见文本]ms 脉冲宽度、0.5[公式:见文本]Hz、25 次试验)来执行的。对两个频段(低:1-4[公式:见文本]Hz;高:10-40[公式:见文本]Hz)进行动态功能连通性分析,以研究早期、高频和晚期、低频刺激引起的反应。与晚期响应相比,早期集中化增加,表明主要激活区域和远处大脑区域之间的直接神经联系具有更突出的作用。将电流注入癫痫发作区 (SOZ) 在反应的早期 (N1) 期间引发了更综合的功能拓扑,而在晚期 (N2) 期间 - 无论刺激部位如何 - SOZ 的连通性都得到了提升与非 SOZ 组织相比。在这两个部分的反应中癫痫子网络的异常行为支持了癫痫中抑制和兴奋机制受损的致病作用的观点。而在晚期 (N2) 期间——无论刺激部位如何——与非 SOZ 组织相比,SOZ 的连通性都升高了。在这两个部分的反应中癫痫子网络的异常行为支持了癫痫中抑制和兴奋机制受损的致病作用的观点。而在晚期 (N2) 期间——无论刺激部位如何——与非 SOZ 组织相比,SOZ 的连通性都升高了。在这两个部分的反应中癫痫子网络的异常行为支持了癫痫中抑制和兴奋机制受损的致病作用的观点。
更新日期:2019-07-29
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