Rheumatoid arthritis (RA) patients from Latin America present distinctive characteristics relevant when assessing their cardiovascular (CV) risk. The objective was to monitor CV risk factor behavior in the early stages of the disease and to identify predictors of major CV outcomes (MACE). A recent-onset RA cohort was initiated in 2004; data from 185 patients with ≥ 1 year of follow-up were analyzed. Patients underwent prospective assessments of CV risk factors. Incident MACE were confirmed according to standardized definitions. Appropriated statics was used based on the distribution of the variables. At baseline, patients were primarily middle-aged females (87.6%), with active disease (69.7%). Most prevalent CV risk factors were C-reactive-protein > 1 mg/L (90.3%), Castelli ratio > 3 (83.8%), and low-high-density lipoprotein levels (73.5%). The number of patients with an incident CV risk factor after 1 year was higher for a Castelli ratio > 3 (23%), low-high-density lipoprotein serum cholesterol (16.3%), high total serum cholesterol (10.6%), and BMI ≥ 30 kg/m2 (10%). A minority of patients met the age-range criteria for the application of ACC/AHA 2013 criteria and Reynolds Risk Score (45.8% and 34.1%, respectively). Fifteen patients were classified with high-CV risk during the first year of follow-up, according to ACC/AHA 2013 criteria. Until June 2018, the cohort underwent 1358 patient/years follow-up; six patients developed incidental MACE; high-CV risk at baseline failed to predict MACE. Recent-onset RA Hispanic patients present a distinctive pattern and first-year behavior of CV risk factors. During follow-up, few patients developed incidental MACE.

中文翻译：

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一项针对西班牙裔类风湿关节炎患者在疾病早期的心血管危险因素行为的一项队列研究。

来自拉丁美洲的类风湿关节炎（RA）患者在评估其心血管（CV）风险时表现出与之相关的独特特征。目的是监测疾病早期的CV危险因素行为，并确定主要CV结果（MACE）的预测因子。2004年开始了最近发作的RA队列研究。对来自≥1年随访的185例患者的数据进行了分析。患者接受了CV危险因素的前瞻性评估。根据标准化定义确认了事件MACE。根据变量的分布使用适当的静态变量。在基线时，患者主要是中年女性（87.6％），患有活动性疾病（69.7％）。最普遍的CV危险因素是C反应蛋白> 1 mg / L（90.3％），Castelli比率> 3（83.8％）和低高密度脂蛋白水平（73.5％）。Castelli比率> 3（23％），低-高密度脂蛋白血清胆固醇（16.3％），高血清总胆固醇（10.6％）和BMI较高，在1年后发生CV危险因素的患者数量更高≥30 kg / m2（10％）。少数患者符合适用ACC / AHA 2013标准的年龄范围标准和雷诺兹风险评分（分别为45.8％和34.1％）。根据ACC / AHA 2013标准，在随访的第一年，有15名患者被分类为具有高心血管风险。直到2018年6月，该队列接受了1358例患者/年的随访。6例患者发生了偶然的MACE；基线时的高CV风险无法预测MACE。近期发作的RA西班牙裔患者表现出独特的模式和CV危险因素的第一年行为。在随访期间，很少有患者发生偶然的MACE。