INTRODUCTION The objective of this study was to analyse the susceptibility to antibiotic of Citrobacter freundii, Klebsiella aerogenes, Enterobacter cloacae, Serratia marcescens, Providencia stuartii and Morganella morganii (CESPM group), detected in urine cultures. METHODS Between 2006 and 2016 we analyzed CESPM group Enterobacteria isolated from urine cultures from both primary health-care centers and Hospital Virgen de las Nieves (Granada). We studied the susceptibility to aminoglycosides, fosfomycin, nitrofurantoin, quinolones, piperacillin/tazobactam, cefepime, imipenem and trimethoprim/sulfamethoxazole following CLSI interpretation criteria. RESULTS A total of 736 isolates were studied: 30.57% E. cloacae, 23.50% M. morganii, 20.38% K. aerogenes, 10.32% C. freundii, 8.83% S. marcescens and 6.38% P. stuartii. A significant decrease in the antibiotic susceptibility was observed. Gentamicin, ciprofloxacin, imipenem and cefepime showed susceptibility over 80%. CONCLUSIONS E. cloacae, M. morganii and K. aerogenes were the most common isolates. Cefepime and imipenem are still a good empiric therapeutic alternative given its activity in vitro.

中文翻译：

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涉及尿路感染的阴沟肠杆菌、摩根氏菌、产气克雷伯菌和弗氏柠檬酸杆菌对抗生素的敏感性演变：一项为期 11 年的流行病学监测研究。

引言 本研究的目的是分析在尿培养物中检测到的弗氏柠檬酸杆菌、产气克雷伯菌、阴沟肠杆菌、粘质沙雷氏菌、普罗维登西亚和摩根氏菌（CESPM 组）对抗生素的敏感性。方法 2006 年至 2016 年期间，我们分析了从初级卫生保健中心和医院 Virgen de las Nieves（格拉纳达）的尿培养物中分离的 CESPM 组肠杆菌。我们按照 CLSI 解释标准研究了对氨基糖苷类、磷霉素、呋喃妥因、喹诺酮类、哌拉西林/他唑巴坦、头孢吡肟、亚胺培南和甲氧苄啶/磺胺甲恶唑的敏感性。结果 共研究了 736 个分离株：30.57% 阴沟肠杆菌、23.50% M. morganii、20.38% K. aerogenes、10.32% C. freundii、8.83% S. marcescens 和 6.38% P. stuartii. 观察到抗生素敏感性显着降低。庆大霉素、环丙沙星、亚胺培南和头孢吡肟的敏感性超过80%。结论 E. cloacae、M. morganii 和 K. aerogenes 是最常见的分离株。鉴于其体外活性，头孢吡肟和亚胺培南仍然是一种很好的经验性治疗替代品。