Multidrug efflux transporters are a plague in the antibiotic resistance mechanisms as they confer the capacity of bacteria to evade most of current therapies. Although these transporters were initially discovered as proton-motive driven pumps, another class of multidrug efflux transporters has emerged in the mid-90s that are powered by ATP hydrolysis. This new class of transporters belongs to one of the largest families of proteins, the ATP-Binding Cassette (ABC) transporters, which are involved in the influx or efflux of a huge variety of molecules. Tremendous progresses have been made in the recent years regarding the functioning mechanism of multidrug efflux ABC transporters, in particular with the accumulation of 3D structures, but many questions remain unsolved. In this review, we will give an overview of our current knowledge on the structure and function of multidrug ABC transporters with an emphasis on bacterial pumps.

中文翻译：

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细菌中的多种药物ABC转运蛋白。

多药外排转运蛋白在抗生素抗性机制中困扰着他们，因为它们赋予细菌逃避当前大多数疗法的能力。尽管最初发现这些转运蛋白是质子驱动泵，但在90年代中期出现了另一类由ATP水解驱动的多药外排转运蛋白。这类新的转运蛋白属于最大的蛋白质家族之一，即ATP结合盒（ABC）转运蛋白，与大量分子的流入或流出有关。近年来，关于多药外排ABC转运蛋白的功能机制，特别是随着3D结构的积累，已经取得了巨大的进步，但许多问题仍未解决。在这篇评论中