Influenza viruses remain a severe burden to human health because of their contribution to overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide sufficient protection to alleviate the annual impact of influenza and cannot confer protection against potentially pandemic influenza viruses. The lack of protection is due to rapid changes of the viral epitopes targeted by the vaccine and the often suboptimal immunogenicity of current immunization strategies. Major efforts to improve vaccination approaches are under way. The development of a universal influenza virus vaccine may be possible by combining the lessons learned from redirecting the immune response toward conserved viral epitopes, as well as the use of adjuvants and novel vaccination platforms.

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通用流感病毒疫苗可能吗？

由于流感病毒对总体发病率和死亡率的贡献，它们仍然是人类健康的沉重负担。当前的季节性流感病毒疫苗不能提供足够的保护以减轻流感的年度影响，也不能针对潜在的大流行性流感病毒提供保护。缺乏保护是由于疫苗靶向的病毒表位的快速变化以及当前免疫策略的免疫原性通常不够理想。正在进行改善疫苗接种方法的重大努力。通过结合从将免疫反应重定向至保守的病毒表位所学到的经验，以及使用佐剂和新型疫苗接种平台，可以开发出通用的流感病毒疫苗。