Several metal-based phosphorus dendrimers were prepared. The first series developed by us was the Cu(II) series. In this series, the most potent is the third generation-Cu(II) showing original mechanism of action with activation of the pro-apoptotic Bax protein. To our knowledge, it is the first example of nanoparticles displaying Bax protein activation and then cell death through apoptosis process. Interestingly, this dendritic-Cu(II) complex showed synergistic effect with doxorubicin. Based on these interesting anti-proliferative activities, we developed Au(III)-conjugated phosphorus dendrimers. The most potent is the third generation-Au(III) dendrimer which represents also a new and promising first-in-class anti-proliferative agent against both solid and liquid tumor cell lines. Then, in order to analyze the influence of the metal moiety distribution of Cu(II) and Au(III) on the surface of dendrimers, mix Cu(II)-Au(III)-conjugated phosphorus dendrimers were also prepared and tested as anti-proliferative agents. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

中文翻译：

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基于金属的磷树枝状大分子作为应对癌症的新型纳米治疗策略：简明概述。

制备了几种基于金属的磷树枝状聚合物。我们开发的第一个系列是Cu（II）系列。在这个系列中，最有效的是第三代Cu（II），它显示了激活促凋亡Bax蛋白的原始作用机理。据我们所知，这是纳米颗粒显示Bax蛋白激活然后通过凋亡过程使细胞死亡的第一个例子。有趣的是，这种树枝状的Cu（II）络合物显示出与阿霉素的协同作用。基于这些有趣的抗增殖活性，我们开发了Au（III）-缀合的磷树枝状聚合物。最有效的是第三代Au（III）树状大分子，它也代表了针对固体和液体肿瘤细胞系的新型且有希望的一流抗增殖剂。然后，为了分析Cu（II）和Au（III）的金属部分分布对树枝状聚合物表面的影响，还制备了混合Cu（II）-Au（III）的磷树枝状聚合物并进行了抗增殖测试代理商。本文归类于：治疗方法和药物发现>肿瘤疾病的纳米药物纳米生物学方法>生物学中的纳米系统。