Mesoporous silica nanoparticles (MSNs) have been widely investigated as a nanocarrier for the delivery of various cargoes in nanomedicine. The application of MSNs in tissue engineering is a relatively newly emerged field that has gained much research interest. In this review, the recent advances in the tissue-engineering application of MSNs are summarized. The controlled synthesis of MSNs is delineated first in terms of tuning the morphology, pore size of MSNs, and its surface chemistry, as well as biodegradability. Then, the different roles of MSNs in tissue engineering are successively introduced, which mainly comprise the delivery of bioactive factors, the inherent bioactivity of MSNs, stem cells labelling, and the impacts of incorporated MSNs on scaffolds. Furthermore, the recent progress in the applications of MSNs for tissue engineering, particularly bone tissue engineering, is summarized in detail. Finally, the challenges or potential trends for the further applications of MSNs in tissue engineering are also discussed. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Implantable Materials and Surgical Technologies > Nanomaterials and Implants.

中文翻译：

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用于组织工程应用的中孔二氧化硅纳米粒子。

介孔二氧化硅纳米颗粒（MSNs）已被广泛研究为纳米载体，用于在纳米药物中输送各种货物。MSN在组织工程中的应用是一个相对较新出现的领域，已经获得了很多研究兴趣。在这篇综述中，总结了MSNs在组织工程应用中的最新进展。首先从调节形态，MSN的孔径，其表面化学以及可生物降解性方面描述了MSN的受控合成。然后，依次介绍了MSN在组织工程中的不同作用，主要包括生物活性因子的传递，MSN固有的生物活性，干细胞标记以及掺入的MSN对支架的影响。此外，MSN在组织工程中的应用的最新进展，尤其是骨骼组织工程，进行了详细总结。最后，还讨论了MSN在组织工程中的进一步应用所面临的挑战或潜在趋势。本文归类于：可植入材料和外科技术>组织修复和置换中的纳米技术可植入材料和外科技术>纳米材料和植入物。