Cellular senescence, a developmental program central to normal aging and aging pathologies, is robustly regulated at the post-transcriptional level. This regulation involves the interaction of RNA-binding proteins and noncoding RNAs with senescence-associated messenger RNAs (mRNAs). There is increasing evidence that these associations are modulated by chemical modifications of specific mRNA nucleotides which can enhance or reduce the binding of regulatory factors. Recent technological advances in mass spectrometry, next-generation sequencing, and genome mapping have improved markedly the detection of mRNA modifications. Given the rising interest in the epitranscriptomic control of gene expression in aging, we discuss our incipient understanding of the chemical mRNA modifications, specifically m6 A and m5 C, that influence cellular senescence. This article is categorized under: RNA Export and Localization > RNA Localization RNA Processing > RNA Editing and Modification.

中文翻译：

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细胞衰老中的 mRNA 甲基化。

细胞衰老是正常衰老和衰老病理学的核心发育程序，在转录后水平受到强有力的调节。这种调节涉及 RNA 结合蛋白和非编码 RNA 与衰老相关信使 RNA (mRNA) 的相互作用。越来越多的证据表明，这些关联是通过特定 mRNA 核苷酸的化学修饰来调节的，这些化学修饰可以增强或减少调节因子的结合。质谱、下一代测序和基因组作图方面的最新技术进步显着改善了 mRNA 修饰的检测。鉴于人们对衰老过程中基因表达的表观转录组控制的兴趣日益浓厚，我们讨论了我们对影响细胞衰老的化学 mRNA 修饰（特别是 m6 A 和 m5 C）的初步理解。本文分类为：RNA 导出和本地化 > RNA 本地化 RNA 处理 > RNA 编辑和修改。