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Two Powerful Tests for Parent-of-Origin Effects at Quantitative Trait Loci on the X Chromosome.
Human Heredity ( IF 1.8 ) Pub Date : 2019-04-09 , DOI: 10.1159/000496987
Pui Yin Lau 1 , Kar Fu Yeung 1 , Ji-Yuan Zhou 2, 3 , Wing Kam Fung 4
Affiliation  

Parent-of-origin effects, which describe an occurrence where the expression of a gene depends on its parental origin, are an important phenomenon in epigenetics. Statistical methods for detecting parent-of-origin effects on autosomes have been investigated for 20 years, but the development of statistical methods for detecting parent-of-origin effects on the X chromosome is relatively new. In the literature, a class of Q-XPAT-type tests are the only tests for the parent-of-origin effects for quantitative traits on the X chromosome. In this paper, we propose two simple and powerful classes of tests to detect parent-of-origin effects for quantitative trait values on the X chromosome. The proposed tests can accommodate complete and incomplete nuclear families with any number of daughters. The simulation study shows that our proposed tests produce empirical type I error rates that are close to their respective nominal levels, as well as powers that are larger than those of the Q-XPAT-type tests. The proposed tests are applied to a real data set on Turner's syndrome, and the proposed tests give a more significant finding than the Q-C-XPAT test.

中文翻译:

对X染色体定量性状位点的原代效应进行两项强大的测试。

原产地效应是表观遗传学中的重要现象,它描述了基因表达取决于其父母起源的情况。用于检测常染色体上的母本效应的统计方法已经研究了20年,但是用于检测X染色体上的母本效应的统计方法的发展相对较新。在文献中,一类Q-XPAT型检验是X染色体上定量性状的原产地效应的唯一检验。在本文中,我们提出了两种简单而强大的测试类别,以检测X染色体上定量性状值的原产地效应。拟议的测试可以容纳有任何数量女儿的完整和不完整的核心家庭。仿真研究表明,我们提出的测试产生的I型经验错误率接近其各自的标称水平,并且其功率大于Q-XPAT型测试的功率。拟议的测试被应用于特纳氏综合症的真实数据集,与QC-XPAT检验相比,拟议的测试具有更重要的发现。
更新日期:2019-11-01
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