Germline genome editing (GGE) holds the potential to mitigate or even eliminate human heritable genetic disease, but also carries genuine risks if not appropriately regulated and performed. It also raises fears in some quarters of apocalyptic scenarios of designer babies that could radically change human reproduction. Clinical need and the availability of alternatives are key considerations in the ensuing ethical debate. Writing from the perspective of a fertility clinic, we offer a realistic projection of the demand for GGE. We lay out a framework proposing that GGE, hereditary genetic disorders, and in vitro fertilization are fundamentally entwined concepts. We note that the need for GGE to cure heritable genetic disease is typically grossly overestimated, mainly due to the underappreciated role of preimplantation genetic testing. However, we might still find applications for GGE in the correction of chromosomal abnormalities in early embryos, but techniques for that purpose do not yet exist.

中文翻译：

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估计对种系基因组编辑的需求：体外受精临床观点。

生殖系基因组编辑（GGE）具有缓解甚至消除人类遗传性疾病的潜力，但如果管理和执行不当，也可能带来真正的风险。在某些可能导致人类生殖彻底改变的设计师婴儿的世界末日场景中，这也引起了人们的担忧。在随后的道德辩论中，临床需求和替代品的可用性是关键考虑因素。从生育诊所的角度出发，我们提供了对GGE需求的现实预测。我们提出了一个框架，建议将GGE，遗传性遗传疾病和体外受精从根本上交织在一起。我们注意到，GGE治疗遗传性遗传疾病的需求通常被严重高估，这主要是由于植入前基因检测的作用未得到充分认识。然而，