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Heritable Genome Editing and the Downsides of a Global Moratorium.
The CRISPR Journal ( IF 3.7 ) Pub Date : 2019-10-01 , DOI: 10.1089/crispr.2019.0016
Kerry Lynn Macintosh 1
Affiliation  

In 2018, Dr. He Jiankui reported that he had edited human embryos and transferred them to a woman, causing her to give birth to twin girls with modified genomes. An international group of scientists and ethicists responded by proposing a global moratorium on heritable genome editing (HGE). In this article, I oppose this proposal on several grounds. A global moratorium might encourage participating nations to ban HGE or postpone access to it indefinitely. It might also deter or delay basic research that could lead to safe and effective HGE. Lastly, a global moratorium might induce participating nations to adopt or maintain laws and regulations that stigmatize children born with modified genomes. As an alternative, I argue that nations should regulate HGE for safety and efficacy only and without distinguishing between therapeutic and enhancing modifications.

中文翻译:

遗传基因组编辑和全球暂停的不利之处。

2018年,何建奎博士报告说,他已经编辑了人类胚胎并将其转移给一名妇女,使她生下了具有改良基因组的双胞胎女孩。一个国际科学家和伦理学家小组的回应是提议全球暂停遗传基因组编辑(HGE)。在本文中,我基于多个理由反对该提议。全球暂停可能会鼓励参与国禁止HGE或无限期推迟使用它。这也可能阻止或推迟可能导致安全有效的HGE的基础研究。最后,全球禁令可能会促使参与国采取或维持法律和法规,以污蔑出生于改良基因组的儿童。作为备选,
更新日期:2019-11-01
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