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Selective distribution of GLUT3-expressing nerve fibers in the lamina terminalis among the circumventricular organs of mice.
Biomedical Research ( IF 1.3 ) Pub Date : 2019-01-01 , DOI: 10.2220/biomedres.40.207
Toshihiko Iwanaga 1 , Kohtarou Konno 1 , Masahiko Watanabe 1
Affiliation  

Sensory circumventricular organs contain the subfornical organ, organum vasculosum of the lamina terminalis (OVLT), and area postrema. Here, immunostaining for GLUT3 in the murine brain selectively labeled the sobfornical organ and OVLT. The immunoreactive neural tract of the subfornical organ formed into thin bundles and extended ventro-rostrally over the anterior commissure. After turning over the commissure, the neural tract passed through the median preoptic nucleus (MnPO) and reached the OVLT; thus, a continuous neural tract expressing GLUT3 connected the subfornical organ, MnPO, and OVLT in the lamina terminalis. In the OVLT, GLUT3-immunoreactive fibers gathered in both the dorsal cap and lateral periventricular zone. Electron microscopically, the immunoreactive structures in the subfornical organ corresponded to nerve fibers or nerve terminals containing many small clear vesicles. The area postrema, another sensory organ, was immunonegative for GLUT3. This study not only presented a useful marker tracing the neural tract in the sensory sites of the lamina terminalis but also suggested a unique system for sensing and determining the metabolism of circulating glucose in the circumventricular organs.

中文翻译:

GLum3表达神经纤维在小鼠的脑室器官之间的终板中的选择性分布。

感觉上的室管器官包含分支下器官,终板层的器官血管(OVLT)​​和后区域。在这里,鼠脑中GLUT3的免疫染色选择性标记了器官器官和OVLT。腋下器官的免疫反应性神经束形成细束,并在前连合部上沿腹膜延伸。翻转合缝后,神经束穿过正中视前核(MnPO)到达OVLT。因此,连续表达GLUT3的神经束连接了椎板末端的亚器官,MnPO和OVLT。在OVLT中,GLUT3免疫反应性纤维聚集在背帽和侧脑室周围区域。电子显微镜 腋下器官的免疫反应结构对应于神经纤维或神经末梢,其中包含许多小的透明囊泡。视网膜后区域,另一个感觉器官,对GLUT3免疫阴性。这项研究不仅提出了一个有用的标记,可以追踪椎板终末感觉部位的神经束,而且还提出了一个独特的系统,用于感测和确定室间隔器官中循环葡萄糖的代谢。
更新日期:2019-11-01
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