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Influence of electromagnetic waves, with maxima in the green or red range, on the morphofunctional properties of multipotent stem cells
Journal of Biological Physics ( IF 1.8 ) Pub Date : 2019-10-08 , DOI: 10.1007/s10867-019-09531-7
A S Chernov 1 , D A Reshetnikov 2 , G K Ristsov 3 , Yu A Kovalitskaya 4 , A M Ermakov 5 , A A Manokhin 2 , A V Simakin 6 , R G Vasilov 1 , S V Gudkov 6, 7
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This paper examines the effect of electromagnetic waves, with maxima in the green or red regions of the spectrum, on the morphofunctional state of multipotent mesenchymal stromal cells. The illumination regimes used in our experiments did not lead to any substantial heating of the samples; the physical parameters of the lighting were carefully monitored. When the samples were illuminated with a green light, no significant photostimulatory effect was observed. Red light, on the other hand, had an evident photostimulatory effect. It is shown that photostimulation with a red light decreases the enzymatic activities of mitochondrial dehydrogenases and enhances the viability of cells, their proliferative activity, and their ability to form bone tissue. It is also established that red light stimulates cell proliferation, while not activating the genes that increase the risk of the subsequent malignant transformation of cells or their death. This paper discusses the possible role of hydrogen peroxide in the processes examined.

中文翻译:

电磁波(最大值在绿色或红色范围内)对多能干细胞形态功能特性的影响

本文研究了电磁波(最大值位于光谱的绿色或红色区域)对多能间充质基质细胞的形态功能状态的影响。我们实验中使用的照明方式不会导致样品的任何实质性加热;照明的物理参数被仔细监测。当用绿光照射样品时,没有观察到显着的光刺激效应。另一方面,红光具有明显的光刺激作用。结果表明,用红光进行光刺激会降低线粒体脱氢酶的酶活性,并增强细胞的活力、增殖活性和形成骨组织的能力。还确定红光刺激细胞增殖,同时不激活会增加随后细胞恶性转化或死亡风险的基因。本文讨论了过氧化氢在所研究的过程中的可能作用。
更新日期:2019-10-08
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