INTRODUCTION A method called sediment cytology includes the investigation of smears arranged from the sediment of the biopsy specimen fixatives. The sediment from this fixative is used to prepare smears and provides a potentially rich source for cytological material. Investigation of the fixative sediment and understanding of the cytological picture with pertinent clinical and radiological information permits diagnosis in a few hours. AIM To evaluate the diagnostic efficacy of sediment cytology and oral brush cytology compared with histopathological findings in oral leukoplakia (OL) cases. METHODS Cytological smears were obtained from 30 clinically diagnosed OL lesions using 2 techniques: oral cytobrush and 10% formalin fixative sedimentation. Both smears were stained with Papanicolaou. Cytological smear evaluation was conducted with respect to cellularity, cell distribution, cellular clumping, and the presence of blood, debris, inflammatory cells, and microbial colonies. The cytopathological scores for all cases were compared between sediment and brush cytology and correlated with the histopathological diagnosis. For statistical analysis, the κ test and the Wilcoxon matched-pair test were used. RESULTS The cytobrush technique had a sensitivity of 83.3% for OL cases histopathologically diagnosed as severe dysplasia, while the sediment cytology technique had a sensitivity of 16.6%. For moderate/mild dysplasia cases, the cytobrush technique had a sensitivity of 7.7%, whereas the sediment technique showed no diagnostic sensitivity. CONCLUSION Based on the results from the present study, sediment cytology, unlike oral brush cytology, is not a useful screening tool for the preliminary diagnosis of potentially malignant oral lesions.

中文翻译：

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口腔白斑中沉积细胞学与口腔刷细胞学的疗效比较。

引言一种称为沉积物细胞学的方法包括研究从活检标本固定剂的沉积物排列的涂片。来自该固定剂的沉积物用于制备涂片，并提供了可能丰富的细胞学物质来源。对固定沉积物的研究以及对细胞学图片的了解以及相关的临床和放射学信息可以在几个小时内完成诊断。目的比较沉积物细胞学和口腔刷细胞学与口腔白斑（OL）病例的组织病理学检查的诊断疗效。方法采用30种临床诊断为OL病变的细胞学涂片，采用两种技术：口服细胞刷和10％福尔马林固定沉淀法。两种涂片均用巴氏染色。进行细胞学涂片评估，涉及细胞数量，细胞分布，细胞团块以及血液，碎片，炎性细胞和微生物菌落的存在。比较所有病例的沉积物和刷细胞学检查的细胞病理学评分，并将其与组织病理学诊断相关。为了进行统计分析，使用了κ检验和Wilcoxon配对检验。结果对于组织病理学诊断为严重不典型增生的OL病例，细胞刷技术的敏感性为83.3％，而沉积物细胞学技术的敏感性为16.6％。对于中度/轻度不典型增生病例，细胞刷技术的敏感性为7.7％，而沉积物技术则无诊断敏感性。结论根据本研究的结果，沉积物细胞学，